Allergy under control – Discover natural ways to support the protective barrier

As allergy season approaches, more and more people are looking for effective methods to relieve their allergy symptoms. Dietary supplements such as quercetin, fisetin, omega acids, NAD+, and calcium are gaining importance as alternatives or complements to traditional antihistamines. In this educational section, we will take a closer look at how these supplements work, their metabolic pathways, and the ways in which they can support the body in fighting allergy symptoms.

Quercetin – The Leading Support in the Fight Against Allergies

Quercetin is a powerful natural flavonoid that acts as an antihistamine. Its anti-inflammatory action is linked to the inhibition of the NF-κB pathway and the reduction of histamine release from mast cells.

• Quercetin degrades histamine by inhibiting the activity of the enzyme histaminase and activating detoxification enzymes such as glutathione S-transferase.

Studies have shown that quercetin supplementation results in the reduction of allergic reactions, making it an interesting alternative to traditional antihistamines.

Synergy of Calcium and Vitamins ADEK

Calcium plays an essential role in the regulation of allergic reactions and the immune response. Mast cells, which are key to the pathogenesis of allergic reactions, release histamine and other inflammatory mediators in response to allergens. Calcium is necessary for the activation and degranulation of mast cells, enabling the release of histamine. The influx of calcium into mast cells is stimulated by allergens and influences the activation of calcium channels.

Vitamin D is also crucial for the immune system, as it supports the differentiation of T and B cells and acts as an immunomodulator. Vitamin D increases calcium absorption in the intestines, which can support mast cell stability and reduce their overreaction to allergens, and may also support antibody production. Studies have shown that vitamin D supplementation can significantly reduce allergy symptoms, and its deficiency is associated with the worsening of asthma symptoms and other allergic diseases.

• Vitamins A and E play important roles in the functioning of the immune system.

Vitamin A, known for its influence on the development of immune cells and the response to infections, helps maintain a healthy mucous membrane barrier, which is crucial for limiting exposure to allergens. Vitamin E acts as a powerful antioxidant, neutralising free radicals, which can reduce inflammation and improve the overall immune response.

The mutual harmony of vitamins ADEK is extremely important for health. Vitamin K, an important component in the synthesis of proteins responsible for blood clotting, interacts with vitamin D in the regulation of calcium metabolism. Together, they support the maintenance of healthy bones, which is crucial for the body's overall fitness. The synergy of vitamin K with vitamin D helps maintain calcium balance in the body and may contribute to the reduction of allergic reactions by stabilising mast cells and limiting their overactivity.

The Power of Omega-3 Acids

Omega-3 fatty acids, found mainly in fish, flaxseeds and walnuts, have a significant impact on the regulation of the immune response and inflammatory processes.

• Acting as precursors for eicosanoids, omega-3s can also influence the synthesis of prostaglandins and leukotrienes, which in turn affects the activity of mast cells.

Increasing the intake of omega-3 acids can lead to a reduction in the production of pro-inflammatory prostaglandins, and thus a reduction in histamine release from mast cells, which may be beneficial in the context of allergies. Furthermore, omega-3s modulate the expression of cyclooxygenase (COX-2), which is crucial for balancing the inflammatory response and reducing hyperreactivity to allergens. Numerous studies suggest that supplementation with omega-3 acids can help alleviate allergy symptoms and increase overall tolerance to allergens by affecting the regulatory mechanisms of the immune system.

The Soothing Properties of Vitamin C

Vitamin C, known for its antioxidant properties, plays a key role in modulating the immune response and alleviating allergy symptoms. Research suggests that vitamin C can reduce histamine production, resulting in weaker allergic reactions. It works by stabilising mast cells, reducing their degranulation and histamine release, which is crucial in allergic reactions.

• Vitamin C supports the function of leukocytes, which translates into an increase in the body's overall immunity.

Studies have shown that vitamin C supplementation can alleviate the symptoms of asthma and other allergic reactions, making it a potential support in allergy therapy.

The Power of B Vitamins

B vitamins, especially B2, B6 and B9, are necessary for the proper synthesis of DNA and RNA, as well as for histamine metabolism.

• An adequate concentration of B vitamins supports the breakdown of histamine by the enzyme monoamine oxidase (MAO) and other detoxification enzymes.

Research suggests that supplementation with a B vitamin complex may support the regulation of the immune response in the context of allergies.

Pantethine is the most biologically active form of vitamin B5 and deserves special mention. It may support the immune response through the modulation of alpha-MSH (alpha-melanotropin). This interaction influences the regulation of inflammation and histamine production, making pantethine relevant in allergy therapy.

Colostrum, Lactoferrin and Immunoglobulins – For Strengthening the Body

Colostrum is the first milk produced by mammals after birth, rich in immunoglobulins, lactoferrin and growth factors. Immunoglobulins, particularly IgA, play a key role in protecting the mucous membranes of the gastrointestinal tract, which influences the modulation of the immune response and the reduction of allergy symptoms.

Scientific research indicates that colostrum supplementation can improve the body's tolerance to allergens, which translates into a reduction in histamine reactions. Studies show that when lactoferrin transports iron into cells, it makes iron less available to microorganisms, leading to a reduction in their proliferation and the limitation of inflammation. This mechanism is particularly important in the context of allergies, where an excessive immune response can lead to the release of histamine.

ATP Energy is an Immune Shield

NAD+ (nicotinamide adenine dinucleotide) is a key coenzyme involved in many metabolic processes, including ATP energy production and protection against oxidative stress.

• Low NAD+ levels are associated with reduced antioxidant capacity and immune function, which can lead to the worsening of allergic reactions.

NAD+ supplementation may support histamine detoxification and strengthen the immune system through glutathione transformations. Magnesium is essential for ATP production and regulates many biochemical processes. Its deficiency can lead to increased sensitivity to histamine and a weakened immune response. Magnesium supplementation supports the healthy functioning of the nervous system and reduces allergy symptoms.

Bifido Guard Max – Because the Gut is the Key to Excellent Immunity

Bifido Guard Max is a blend of bifidobacteria that support gut health and the regulation of the immune system. Research suggests that probiotics can limit inflammation and regulate histamine metabolism by supporting the integrity of the intestinal barrier, which prevents the absorption of histamine.

Effective Complement to the Fight Against Allergies: Antioxidant Support

Fisetin is another flavonoid that exhibits anti-inflammatory and antioxidant effects. Studies have shown that fisetin acts by inhibiting the NF-κB pathway and reducing histamine production from mast cells. Fisetin's antioxidant activity also influences the regulation of oxidative stress, which is important in the context of allergies and inflammation.

Resveratrol is a polyphenol with antioxidant and anti-inflammatory effects. Its action is based on the modulation of the AMPK pathway, which plays a key role in the regulation of energy metabolism. Resveratrol reduces the production of pro-inflammatory cytokines, which can alleviate allergy symptoms. Additionally, resveratrol supports the protection of cells against oxidative stress, which has a beneficial effect on the immune system.

Matcha, a form of green tea, is rich in polyphenols, including EGCG, which have antioxidant effects. Matcha supplementation shows potential in reducing allergy symptoms due to its inhibitory effect on histamine release and regulation of the immune response, which reduces inflammation.

EGCG is a catechin that exhibits strong antioxidant and anti-inflammatory properties. Research suggests that EGCG can block the release of histamine and cytokines from mast cells by inhibiting the H1 receptor. The action of EGCG is supported by the activation of detoxification enzymes, which may support the immune response and reduce allergic reactions.

NAC (N-acetylcysteine) is a precursor to glutathione, a powerful antioxidant. It helps in the detoxification of histamine and the reduction of allergic reactions by increasing the production of glutathione, which supports the body's natural defence mechanisms. Glutamine supports intestinal integrity, and glycine acts as a neurotransmitter, supporting the body's immune capabilities.

Summary

Allergy season does not have to mean a struggle, but can mean conscious support. It is important to understand what works for your specific type of allergic reaction. The gut, mucous membranes, ATP energy levels and immune balance form a system that either reacts calmly to an allergen or triggers an excessive response.

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