Larazotide acetate

Larazotide acetate 60caps/250mcg 

Most people have an idea of ​​how important the microbes that inhabit our gut are, or how important the health of the intestinal barrier, i.e., the intestinal mucosa, is. It determines what is absorbed from our digestive tract and what is eliminated.

We have many microvilli along the digestive tract, which are finger-like projections that increase the absorption area in our intestines and help us absorb all the nutrients, but if they become damaged, it can lead to "leaking" of the intestinal barrier, aka leaky gut syndrome.

What causes leaky gut?

1. alcohol abuse

2. antibiotics and other drugs

3. toxins (bisphenols and others)

4. chronic stress

5. Nutrient deficiencies

Larazotide Acetate is a first-in-class regulator of intestinal villi tight junction (TJ) being developed as an adjunct to a gluten-free diet. Prevents TJ from opening by promoting TJ folding and actin filament rearrangement, which prevents gluten from entering the intestinal submucosa and triggering an inflammatory response.

Larazotide is an oral peptide derived from zonula occludens that acts as a tight junction regulator and zonulin antagonist. Tight junctions, also known as closure junctions or zonulae occludentes (singular, zonula occludens), are multi-protein junction complexes whose function is to prevent the leakage of solutes and water and to seal between epithelial cells. They also play a key role in maintaining the structure and permeability of endothelial cells. Tight junctions can also serve as leaky pathways, creating selective channels for small cations, anions, or water.

Larazotide binds to gut apical cell receptors and antagonizes zonulin, preventing the opening of epithelial tight junctions caused by gluten/gliadin, glyphosate, pro-inflammatory cytokines, zonulin bacterial antigens such as lipopolysaccharide (LPS) and bacterial dysbiosis.

Product intended for research purposes

Additional informations:

• The product (substance) isn't a food or diet supplement and is not suitable for human consumption.
• Keep out of children's reach
• Keep container tightly closed.
• Store in a dry, cool and shaded place; protect from moisture.
• Store only in the original container.
• Avoid contact during pregnancy and breast feeding.
• Consult a doctor in the event of feeling unwell or having adverse effects related to the contact with the substance.