KANNA 25mg/capsule

KANNA 25mg / 60 capsules

Sceletium tortuosum (L.) N.E.Br. (Mesembryanthemaceae), commonly known as Kanna or Kougoed, is an effective native medicinal plant in South Africa, especially for the native San and Khoikhoi tribes. Today, the plant has gained strong appeal and reputation worldwide for its ability to promote well-being by relieving stress with a calming effect. In the past, the plant was used by indigenous San hunter-gatherers and the Khoi people to quench thirst, fight fatigue, and for medicinal, social and spiritual purposes. 

Why it's worth it.

1. enhances the action of serotonin (acts as a reuptake inhibitor)-that is, the so-called happiness hormone

2. helps to endure difficult and stressful situations

3. makes it easier to stay focused for longer periods of time

4. is one of the few substances with calming and pro-cognitive properties

5. increases the amount of cAMP in nerve cells - which translates into improved memory

6. the product is excellent for stressed people, people with depressed mood or those who face a heavy mental effort in the second part of the day (e.g. students studying for exams)

Preclinical animal data, providing mechanistic insights into Kanna, show the action of this plant on serotonin and a specific enzyme known as phosphodiesterase-4 (PDE4) through the main bioactive alkaloids present in this unique plant. This synergistic dual action on the central nervous system supports canna's ability to enhance or improve mood and promote relaxation." * (At the same time). Specifically, when it comes to serotonin, the alkaloids in kanna enhance the serotonin reuptake inhibitory effects in the brain, thereby increasing serotonin levels, or in simpler language - These compounds help kanna delay the body - particularly neurons - from rapidly reabsorbing serotonin, ultimately increasing its availability and activity in our brain and body. Needless to say, kanna can be a game changer in balancing emotions, as serotonin plays a key regulatory role in supporting mood, behavior and other important nervous system-related functions. These actions are also supported by evidence from clinical studies, which have shown that canna promotes stress resilience by demonstrating positive effects on the brain's emotional response. The unique adaptogenic plant Sceletium tortuosum has been shown in clinical studies using advanced MRI brain imaging to buffer our brains against stress by positively influencing our neural circuits.

In a six-week clinical trial, daily intake of Zembrin® Kanna extract significantly increased alpha1 and alpha2 brain frequencies during various cognitive tasks. The result is what we call "alert calm." As Jeremy Appleton, N.D., director of scientific and medical affairs at PLT Health Solutions, explains: "Clinical studies have shown effects on improving executive function and cognitive flexibility, while decreasing activity in the part of the brain that registers threat and stress."

The mechanisms behind these beneficial cognitive effects are thought to be driven by the effects of stress resistance on key brain circuits, as well as the mood-enhancing effects of blocking serotonin reuptake (i.e., keeping it longer) and inhibiting the PDE4 enzyme. Several of these key mechanisms have been elucidated in important preclinical studies. The PDE4 enzymatic pathways are major cascades involving cellular signals for processes such as apoptosis (programmed cell death), neuroplasticity and neuronal connectivity, and PDE4 inhibition has anti-inflammatory and life-extending implications at the cellular level.

Cognitive flexibility is the ability to adjust our thoughts and actions based on our environment, demonstrating agility and flexibility in our thinking and actions, and allows us to switch seamlessly between mental tasks (i.e., task-switching), which has obvious implications for juggling life like a pro.

Between preclinical6 animal studies and clinical studies of safety and tolerability in humans (not to mention a long history of traditional use), cannabis has demonstrated a strong safety profile. In clinical studies at doses up to 50 milligrams, significant side effects or complaints are simply not common. In addition, most clinical studies involve doses of 25 to 50 milligrams, so higher doses are unnecessary when trying to harvest the targeted brain benefits of this particular botanical bioactive agent.